In addition, the general condition of the patients was evaluated by the treating physician using the 8-point Physician’s Global Evaluation (PGE) scale. At the end of the study, 83.3% (6,016) of patients had ‘good to excellent’ general condition compared with 31.9% (2,302) at the start.1
“Physical activity is an important part of the management of COPD. It is crucial that patients remain active, so they can achieve better long-term outcomes and enjoy a higher quality of life,” said Associate Professor Arschang Valipour, Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Vienna, Austria, and Lead Investigator for the OTIVACTO trial. “We already know from clinical trials that tiotropium/olodaterol can make it easier for people with COPD to stay active by reducing symptoms and the difficulties related to physical activity. In this observational OTIVACTO study, we saw a similar effect; tiotropium/olodaterol increased patients’ ability to be active in their daily lives.”
Adherence to maintenance therapy is essential for therapeutic success in COPD.2 The ability to properly inhale from the inhalation device plays a key role as it is important to transport the medication deep into the lungs where it can reach the small airways.3,4 In the OTIVACTO study, more than 80% of patients were satisfied or very satisfied with both their inhalation experience and the handling of their Respimat® device, as well as with tiotropium/olodaterol treatment overall.1
“Real-world data complement the evidence from clinical trials and help us understand the effects of a medicine in everyday clinical practice. This in turn helps inform physicians’ decisions for the management of their patients,” said Dr Alberto de la Hoz, Global Medical Lead COPD and Asthma, Therapeutic Area Respiratory at Boehringer Ingelheim. “The OTIVACTO study presented at the ERS International Congress showed that patients receiving tiotropium/olodaterol therapy reported improvement in their general condition and ability to better manage their daily routines. It also showed high patient satisfaction with the Respimat®device, both for inhaling and handling.”
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For references and notes to editors, please visit: http://www.boehringer-ingelheim.com/press-release/real-world-study-reports-effects-spiolto-respimat
i PF-10 is a sub-set of the validated SF-36 patient–reported quality-of-life questionnaire
ii Global Initiative for Chronic Obstructive Lung Disease
iii GOLD guideline uses a combined COPD assessment approach to group patients according to symptoms and previous history of exacerbations:
GOLD A: Low symptom severity, low exacerbation risk
GOLD B: High symptom severity, low exacerbation risk
GOLD C: Low symptom severity, high exacerbation risk
GOLD D: High symptom severity, high exacerbation risk
